DNA encoding peripheral-type benzodiazipine receptor...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S070100, C435S252300, C435S320100, C435S325000, C435S071100, C536S023100, C536S023500, C530S350000

Reexamination Certificate

active

07056694

ABSTRACT:
The present invention relates to nucleic acids encoding peripheral-type benzodiazepine receptor (PBR)-associated proteins (PAPs), and nucleic acids that hybridize or are variant of nucleic acids encoding the peripheral-type benzodiazepine receptor (PBR)-associated proteins (PAPs), which are capable of encoding proteins that regulate the function of PBRs affecting both steroid biosynthesis and mediating cholesterol delivery as well as other PBR-mediated functions.

REFERENCES:
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5948676 (1999-09-01), Chang et al.
patent: 2003/0157095 (2003-08-01), Papadopoulos
patent: WO-9949316 (1999-09-01), None
patent: WO-0001821 (2000-01-01), None
patent: WO-0009549 (2000-02-01), None
Rao RM et al. Regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of the cholesterol transfer proteins StAR and PBR. Endocr Res. 28(4):387-394, 2002.
Papadopoulos, V et al. In vivo studies on the role of the peripheral benzodiazepine receptor (PBR) in steroidogenesis. Endocr Res. 24(3-4):479-487, 1998.
Papadopoulos V et al. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids. 62(1):21-28, 1997.
Papadopoulos V et al. Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis, J Steroid Biochem Mol Biol. 53(1-6):103-110, 1995.
Li, H et al. Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology. 139(12):4991-4997, 1998.
Li, H e tal. Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RI alpha)-associated protein. Molec Endocrinol 15(12):2211-2228, 2001.
Li et al. Accession No. AF022770, direct submission, Oct. 2, 1997.
Zisterer et al. Identification of novel ligands for the peripheral-type benzodiazepine receptor. Biochem Soc Trans. 23(2):371S, 1995.
Hauet et al. PBR, StAR, and PKA: partners in cholesterol transport in steroidogenic cells. Endocr Res. 28(4):395-401, 2002.
Culty M et al. In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis. J Steroid Biochem Mol Biol. 69(1-6):123-130, 1999.
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech 18(1): 34-39, 2000.
Bork, A. Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res 10: 398-400, 2000.
Doerks et al. Protein annotation: detective work for function prediction. Trends in Genetics 14(6): 248-250, 1998.
Smith et al. The challenges of genome sequence annotation or “The devil is in the details”. Nature Biotech 15: 1222-1223, 1997.
Brenner, S.E. Errors in genome function. Trends in Genetics 15(4):132-133, 1999.
Bork et al. Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12(10): 425-427, 1996.
Wells. J.A. Additivity of mutational effects in proteins. Biochemistry 29 (37): 8509-8517, 1990.
Ngo et al. Computational complexity, protein structure prediction, and the Levinthal paradox. The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Phillips, A. The challenge of gene therapy and DNA delivery. J Pharm Pharmcol 53: 1169-1174, 2001.
Kapur et al. The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects i Steel17H mice. Blood (94)6: 1915-1925, 1999.
Sher et al. Mutations uncouple human fibroblast growth factor (FGF)-7 biological activity and receptor binding and support broad specificity in the secondary receptor binding site of FGFs. J Biol Chem 274(49): 35016-35022, 1999.
Wuyts et al. NH2- and COOH-terminal truncations of murine granulocyte chemotactic protein-2 augment the in vitro and in vivo neutrophil chemotactic potency. J Immunol 163: 6155-6163, 1999.
Li H et al. (2001) “Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein,”Mol Endocrinol15: 2211-28.
Don, J., “M. musculus mRNA megi”,Database EMBL [Online] AC X64455, Jul. 26, 1993.
Galiegue, S. , et al., “Cloning and Characterization of PRAX-1—A New Protein that Specifically Interacts with the Peripheral Benzodiazepine Receptor”,The Journal of Biological Chemistry, 274(5), (1999),2938-2952.
Garnier, M. , et al., “Diazepam Binding Inhibitor is a Paracrine/Autocrine Regulator of Leydig Cell Proliferation and Steroidogenesis: Action via Peripheral-Type Benzodiazepine Receptor and Independent Mechanisms”,Endocrinology, 132(1), (1993),444-458.
Hardwick, M. , et al., “Abstract #1569 The Peripheral-type Benzodiazepine Receptor in Human Breast Cancer”,Proceedings of the American Association for Cancer Research, 38 (1997),233.
Hardwick, M. , et al., “Peripheral-Type Benzodiazepine Receptor (PBR) in Human Breast Cancer: Correlation of Breast Cancer Cell Aggressive Phenotype with PBR Expression, Nuclear Localization, and PBR-mediated Cell Proliferation and Nuclear Transport of Cholesterol”,Cancer Research, 59(4), (1999),831-842.
Kozikowski, A. P., et al., “Synthesis and Biology of a 7-Nitro-2,1,3-benzoxadiazol-4-yl Derivative of 2-Phenylindole-3-acetamide: A Fluorescent Probe for the Peripheral-Type Benzodiazepine Receptor”,Journal of Medicinal Chemistry, 40(16), (1997),2435-2439.
Krueger, K. E., et al., “Peripheral-type Benzodiazepine Receptors Mediate Translocation of Cholesterol from Outer to Inner Mitochrondrial Membranes in Adrenocortical Cells”,The Journal of Biological Chemistry, 265(25), (1990),15015-15022.
Li, H. , et al., “Mus musculus peripheral benzodiazepine receptor associated protein”,Database EMBL [Online] AC AF022770, (Oct. 2, 1997).
Marra, M. , et al., “mo98e12.rl Stratagene mouse testis (#937308) Mus musculus cDNA clone”,Database EMBL [Online] AC AA174581, Mar. 3, 2000.
Miettinen, H. , et al., “Expression of Peripheral-Type Benzodiazepine Receptor and Diazepam Binding Inhibitor in Human Astrocytomas: Relationship to Cell Proliferation”,Cancer Research, 55, (1995),26912695.
Moser, P. C., “Protentiation of 5-Methoxy-N,N-Dimethyltryptamine-Induced Head-Twitches by Diazepam: Evidence for Involvement of Adenosine Uptake Inhibition”,Drug Development Research, 30(4), (1993),213-218.
Papadopoulos, V. , et al., “Targeted Disruption of the Peripheral-Type Benzodiazepine Receptor Gene Inhibits Steroidogenesis in the R2C Leydig Tumor Cell Line”,The Journal of Biological Chemistry, 272(51), (1997),32129-32135.
Pawlikowski, M. , et al., “Inhibition of Cell Proliferation of Human Gliomas by Benzodiazepinesin vitro”, Acta Neurol Scand., 77, (1988),231-233.
Sambrook, J. , et al.,Molecular Cloning—a Laborary Manual, 2d Edition, Cold Spring Laboratory Press,(1989)9.47-9.62.
Ahn, A. H., “The Structural and Functional Diversity of Dystrophin”,Nature Genetics, 3, (Apr., 1993),283-291.
Boyle, T P., et al., “Structure of the murine gene encoding apolipoprotein A-1.”,Gene, 117(2), (Aug. 15, 1992),243-7.
Cawthon, R. M., et al., “cDNA Sequence and Genomic Structure of EV12B, a Gene Lying within an Intron of the Neurofibromatosis Type 1 Gene”,Genomics, 9, (1991),446-460.
Don, J , et al., “Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle”,Cell Growth Differ., 3(8), (Aug. 1992),495-505.
Don, J. et al., “M.musculus mRNA meg1”,Database EMBL AC X64455, Jul. 26, 1993.
Ever, L , et al., “Two alternatively spliced Meig1 messenger RNA species are differentially expressed in the somatic and in the germ-cell compartments of the testis”,Cell Growth Differ., 10(1), (Jan. 1999),19-26.
Farges, R , et al., “

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