DNA encoding p107 tumor suppressor and related polypeptides

Details DNA encoding p107 tumor suppressor and related polypeptides DNA encoding p107 tumor suppressor and related polypeptides

1993-11-15

1999-10-05

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, 536 235, 536 243, C12N 510, C12N 1563, C12N 1512

Patent

active

059623152

ABSTRACT:
A cDNA encodes p107; a cell contains recombinant p107-encoding DNA; and substantially all of the cells of a nonhuman mammal contain recombinant p107-encoding DNA. Also, a method for diagnosing a condition of tumorigenicity in a subject, includes the steps of obtaining a tissue sample from the subject and detecting the presence of non wild-type p107-encoding gene in the sample, or detecting the absence of wild-type p107-encoding gene in the sample; or extracting DNA from the sample and detecting the presence of non wild-type p107-encoding gene or the absence of wild-type p107-encoding gene in the DNA. Also, a nucleic acid probe is complementary to a portion of a human mutant p107 gene.

REFERENCES:
patent: 5262321 (1993-11-01), Livingston et al.
Mark E. Ewen et al., Molecular Cloning, Chromosomal Mapping, and Expression of the cDNA for p107, a Retinoblastoma Gene Product-Related Protein, Sep. 20, 1991, Cell, vol. 66:1155-1164.
Peter Whyte et al., Cellular Targets for Transformation by the Adenovirus E1A Proteins, Cell, Jan. 13, 1989, vol. 56:67-75.
Ed Harlow et al., Association of Adenovirus Early-Region 1A Proteins with Cellular Polypeptides, May 1986, Molecular and Cellular Biology, vol. 6, No. 5:1579-1589.
Mark E. Ewen et al., An N-Terminal Transformation-Governing Sequence of SV40 Large T Antigen Contributes to the Binding of Both p110.sup.Rb and a Second Cellular Protein, p120, Jul. 28, 1989, Cell, vol. 58:257-267.
Kenneth Jacobs et al., Isolation and Characterization of Genomic and cDNA Clones of Human Erythropoietin, Feb. 28, 1985, Nature, vol. 313:806-810.
Nicholas Dyson et al., The Cellular 107K Protein That Binds to Adenovirus E1A Also Associates with the Large T Antigens of SV40 and JC Virus, Jul. 28, 1989, Cell, vol. 58:249-255.
Yeung et al., "The Retinoblastoma-Related Gene, RB2, Maps to Human Chromosome 16q12 and rat Chromosome 19", Oncogene 8:3465-8, 1993.
Xavier Mayol et al., "Cloning Of A New Member Of The Retinoblastoma Gene Family (pRb2) Which Binds To The E1A Transforming Domain", Oncogene 1993 Sep., 8(9):2561-6.
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