DNA encoding p107 tumor suppressor

Details DNA encoding p107 tumor suppressor DNA encoding p107 tumor suppressor

1991-05-31

1993-11-16

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352523, 43525233, 536 235, C12N 1512, C12N 1570, C12N 121, C12N 510

Patent

active

052623211

ABSTRACT:
A cDNA encodes p107; a cell contains recombinant p107-encoding DNA; and substantially all of the cells of a nonhuman mammal contain recombinant p107-encoding DNA. Also, a method for diagnosing a condition of tumorigenicity in a subject, includes the steps of obtaining a tissue sample from the subject and detecting the presence of non wild-type p107-encoding gene in the sample, or detecting the absence of wild-type p107-encoding gene in the sample; or extracting DNA from the sample and detecting the presence of non wild-type p107-encoding gene or the absence of wild-type p107-encoding gene in the DNA. Also, a nucleic acid probe is complementary to a portion of a human mutant p107 gene.

REFERENCES:
Ewen, et al., "An N-Terminal Transformation-Governing Sequence of SV40 Large T Antigen Contributes to the Binding of Both p110Rb and a Second Cellular Protein, p120", Jul. 28, 1989, Cell, vol. 58, pp. 257-267.
Whyte, et al., "Cellular Targets for Transformation by the Adenovirus E1A Proteins", Jan. 13, 1989, Cell, vol. 56, pp. 67-75.
Harlow, et al., "Association of Adenovirus Early-Region 1A Proteins with Cellular Polypeptides", May, 1986, Molec. and Cell. Biol., vol. 6, No. 5, pp. 1579-1589.
Dyson et al. (1989), Cell 58: 249-255.
Jacobs et al. (1985), Nature 313: 806-810.

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