DNA encoding novel polypeptide having Factor Xa inhibitory activ

Details DNA encoding novel polypeptide having Factor Xa inhibitory activ DNA encoding novel polypeptide having Factor Xa inhibitory activ

1995-06-06

1998-07-21

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 4353201, 435193, 536 231, C07K 1481, C07K 14815, C12N 1515

Patent

active

057834210

ABSTRACT:
A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism containing cDNA encoding the polypeptide has been deposited in the ATCC under Accession No. 69134. Recombinant microorganisms able to produce the polypeptide have been deposited in the ATCC under Accession Nos. 69135, 69137 and 69269.

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