DNA encoding novel enzyme having D-serine synthase activity,...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

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C435S183000, C536S023200

Reexamination Certificate

active

07919285

ABSTRACT:
This invention relates to DNA encoding an enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.

REFERENCES:
patent: 1331274 (2003-07-01), None
patent: 58-116690 (1983-07-01), None
patent: 5-168484 (1993-07-01), None
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Ji-Quan Liu et al.; “A Novel Metal-activated Pyridoxal Enzyme with a Unique Primary Structure, Low Specificity D-Threonine Aldolase fromArthrobactersp. Strain DK-38”; The Journal of Biological Chemistry; 1998; pp. 16678-16685; vol. 273, No. 27.
Database EMBL, “Achromobacter xylosoxidans, D-threonine aldolase”, Aug. 6, 2000, XP002451106, retrieved from EBI, Database Accession No. AB026892.
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Michihiko Kataoka et al., “Isolation and characterization of D-threonine aldolase, a pyridoxa1-5′-phosphate-dependent enzyme fromArthrobactersp. DK-38”, European Journal of Biochemistry, 1997, pp. 385-393, vol. 248, No. 2, XP001536684, ISSN: 0014-2956.
Ji-Quan Liu et al., “Diversity of microbial threonine aldolases and their application”, Journal of Molecular Catalysis β Enzymatic, Sep. 4, 2000, pp. 107-115, vol. 10, No. 1-3, XP009089566, ISSN: 1381-1177.

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