Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2005-03-22
2005-03-22
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S018000, C435S108000, C435S069100, C435S320100, C435S252300, C435S106000, C530S350000, C536S023200
Reexamination Certificate
active
06869788
ABSTRACT:
This invention provides a novel D-aminoacylase obtained by cloning a DNA encoding the novel D-aminoacylase from Methylobacterium mesophilicum MT 10894, etc. and which shows sufficiently high activity at an industrially useful substrate concentration to allow a D-amino acid to be efficiently produced from an N-acyl-DL-amino acid; a DNA encoding the D-aminoacylase; a process for producing a D-amino acid from the corresponding N-acylamino acid using a transformant containing the DNA.
REFERENCES:
patent: WO 0023598 (2000-04-01), None
patent: WO 0078926 (2000-12-01), None
Witkowski et al., Biochemistry 38:11643-11650, 1999.*
Broun et al., Science 282:1315-1317, 1998.*
Seffernick et al., J. Bacteriol. 183(8):2405-2410, 2001.*
Wakayama, M. et al., Cloning and Sequencing of a Gene Encoding D-Aminoacylase fromAlcaligenes xylosoxydanssubsp.xylosoxydansA-6 and Expression of the Gene inEscherichia coli, Biosci. Biotech. Biochem., 1995, vol. 59, no. 11, pp. 2115-2119.
Wakayama, M. et al., Cloning, Expression and Nucleotide Sequence of the N-Acyl-D-Aspartate Amidohydrolase Gene fromAlcaligenes xylosoxydanssubsp.xylosoxydansA-6, Journal of Fermentation and Bioengineering, 1995, vol. 80, No. 4, pp. 311-317.
Wakayama, M. et al., Primary Structure of N-Acyl-D-Glutamate Amidohydrolase fromAlcaligenes xylosoxydanssubsp.xylosoxydansA-6, J. Biochem., 1995, vol. 118, pps. 204-209.
Arii Teruo
Oikawa Toshihiro
Osabe Masami
Takahashi Katsuyuki
Yamaki Toshifumi
Burns Doane Swecker & Mathis L.L.P.
Mitsui Chemicals Inc.
Prouty Rebecca E.
Ramirez Delia M.
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