DNA encoding novel antimicrobial polypeptide and methods for obt

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352401, 4353201, 435255, 4352523, 536 231, 536 235, 514 12, C12N 1512, C12N 121, C12P 2102

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active

052100278

ABSTRACT:
This invention provides a purified polypeptide useful as an antimicrobial agent. This purified polypeptide has been derived from human granulocytes, and has a molecular weight of about 3,700 daltons and the N-terminal amino acid sequence val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr-glu-leu-arg-val-gly-asn-cy s-leu-ilu-gly-gly-val-ser-phe-thr-tyr-cys-cys-thr-arg-val. This invention also provides methods for producing this polypeptide, pharmaceutical compositions containing the polypeptide, and uses thereof.

REFERENCES:
patent: 4705777 (1987-11-01), Lehrer et al.

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