Chemistry: molecular biology and microbiology – Vector – per se
Patent
1990-09-27
1993-04-13
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Vector, per se
435 6951, 4352401, 530399, 536 235, 536 231, C07H 1512, C07K 1300
Patent
active
052024288
ABSTRACT:
Proteins isolated from novel clonal cell lines grown in culture are mitogenic for fibroblasts, and glial cells; some promote nerve cell survival and are prospectively useful in treating diseases such as Parkinson's and Alzheimer's which result in cell death in the nervous system, as well as in treating patients prone to epileptic seizures and patients suffering from trauma to the CNS. Certain of these proteins may be useful in nerve regeneration as well as in treating such diseases and injuries. Some are particularly useful in promoting lung development. The proteins can be topically applied in suitable compositions for wound-healing applications, and they can be administered parenterally to promote lung development and to treat patients afflicted with nerve damage and/or nerve disease.
REFERENCES:
Bowie et al. Science 247: 1306-1310 (1990).
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Watters et al. J of Neurochem 49(3):705-713 (1987).
Wagner J. of Neuroscience 6(1):61-67 (1986).
Heymanns et al. Proc. Natl. Acad Sci. 84:7758-62(1987).
Nature, vol. 249, No. 5454, pp. 224-227 (May 17, 1974) Schubert, et al., "Clonal cell lines from the rat central nervous system".
Proc. Natl. Acad. Sci. USA, vol. 76, No. 1, pp. 514-517 (Jan. 1979) Bottenstein, et al., "Growth of a rat neuroblastoma cell line in serum-free supplemental medium".
Proc. Natl. Acad. Sci. USA, vol. 84, pp. 7768-7772 (Nov. 1987) Porter, et al. "Release of autocrine growth factor by primary and immortalized Schwann cells".
Annals of Neurology, vol. 20, No. 3, pp. 317-322 (Sep. 1986) Brockes, et al., "Glial Growth Factor-Like Activity in Schwann Cell Tumors".
Guest Shelly J.
Hill Jr. Robert J.
The Salk Institute for Biological Studies
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