DNA encoding nestin protein

Details DNA encoding nestin protein DNA encoding nestin protein

1992-03-19

1994-08-16

Parr, Margaret

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, 435 6, 435912, 935 9, 935 11, 935 78, C07H 2104, C12Q 168

Patent

active

053388399

ABSTRACT:
A gene (SEQ ID NO: 1 or SEQ ID NO: 3) encoding a protein, nestin, whose expression distinguishes neural multipotential stem cells and brain tumor cells from the more differentiated neural cell types (e.g., neuronal, glial and muscle cells).

REFERENCES:
Lendahl, U., et al., "CNS Stem Cells Express a New Class of Intermediate Filament Protein", Cell, 60:585-595 (Feb. 23, 1990).
McKay, R. D., "A cerebeller stem cell model for meduiloblastona" (Abstr. 10.30.08) Cancer Research & Clinical Oncology, 116 (1990).
Zimmerman et al., "Molecular Cloning of Nestin: A Novel Intermediate Filament Restriction to CNS Stem Cells" (Abst. B121); Cancer Research and Clinical Oncology 116 (1990).
McKay R. D., et al., "Molecular cloning of nestin: a novel intermediate filament restricted to CNS stem cells", J. Cell. Biochem. Suppl., p. 223 (1990).
Jat., P. S., et al., "Large T. Antigens of Simian Virus 40 and Polymavirus Efficiently Establish Primary Fibroblasts", J. of Virol. 59(3):746-750 (1986).
Chou, J. Y., "Establishment of Rat Fetal Liver Lines and Characterization of Their Metabolic and Hormonal Properties: Use of Temperature-Sensitive SV40 Virus", Methods in Enzym. 109:385-395 (1985).
Jat, P. S., et al., "Recombinant Retroviruses Encoding Simian Virus 40 Large T Antigen & Polyomavirus Large & Middle T Antigens", Mol. & Cell. Biol. 6(4):1204-1217 (1986).
Hockfield, S., et al., "Identification of Major Cell Classes in the Developing Mammalian Nervous System", J. of Neuroscience 5(12):3310-3328 (1985).
Frederiksen, K., et al., "Proliferation & Differentiation of Rat Neuroepithelial Precursor Cells in vivo", J. of Neuroscience Annl. 8(4):1155-1151 (1988).
Jat, P. S., et al., "Cell Lines Established by a Temperature-Sensitive Simian Virus 40 Large-T-Antigen Gene are Growth Restricted at the Nonpermissive Temperature", Mol. & Cell. Biol. 9(4):1672-1681 (1989).
Frederiksen, K., et al., "Immortalization of Precursor Cells from the Mammalian CNS", Neuron 1:439-448 (1988).
Watanabe, T., et al., "Rod Photoreceptor Development In Vitro: Intrinsic Properties of Proliferating Neuroepithelial Cells Change as Development Proceeds in the Rat Retina", Neuron 4:461-467 (1990).
Reh, T. A., et al., "Age of Differentiation Determines Rat Retinal Germinal Cell Phenotype: Induction of Differentiation by Dissociation" J. of Neuroscience 9(12):4179-4189 (1989).
Temple, S., et al., "Clonal Analysis of Oligodendrocyte Development in Culture: Evidence for a Developmental Clock that Counts Cell Divisions" Cell 44:773-779 (1986).
International Search Report; Patent Cooperation Treaty Search Report PCTUS92101375.
Petit, C. A., et al., "Immortalization of Rodent Embryo Fibroblasts by SV40 is Maintained by the A Gene", Virology 127:74-82 (1983).
Beug, H., et al., "Hormone-Dependent Terminal Differentiation in Vitro of Chicken Erythroleukemia Cells Transformed by ts Mutants of Avian Erythroblastosis Virus", Cell 28:907-919 (1982).
Frederiksen, K., et al., "Immortalization of Precursor Cells from the Mammalian CNS", Neuron 1:439-448 (1988).
Lendahl, U., et al., "CNS Stem cells express a new class of Intermediate filament protein", Cell 60:585-595 (1990).
Valtz, N. L. M., et al., "An Embryonic Origin for Medulloblastoma" The New Biologist, 3(4):364-371 (1991).
Redies, C., et al., "Differentiation and Heterogeneity in T-Antigen Immortalized Precursor Cell Lines From Mouse Cerebellum", J. of Neurosci. Res., 30:601-615 (1991).
Tohyama, T., et al., "Nestin Expression in Embryonic Human Neuroepithelium and in Human Neuroepithelial Tumor Cells", Laboratory Investigation 66(3):303-313 (1992).

Affiliated with

Also associated with

Rating

DNA encoding nestin protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA encoding nestin protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding nestin protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-952948