DNA encoding natural killer lytic associated protein

Details DNA encoding natural killer lytic associated protein DNA encoding natural killer lytic associated protein

1995-03-02

1997-09-09

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Insect cell, per se

4351725, 4353205, 435325, 43525233, 435372, 536 231, 536 235, C12N 1500, C12N 500, C07H 2104

Patent

active

056655886

ABSTRACT:
A unique gene sequence encoding a natural killer lytic associated molecule (natural killerlytic associated protein) has been isolated. Using recombinant DNA techniques, the natural killerlyric associated protein may be produced in useful quantities. Methods for preparing the gene sequence and the gene product are disclosed, as well as methods of using the product to enhance anti-tumor, anti-viral and anti-microbial activity of natural killer cells. A method of inhibiting expression of the gene product is also disclosed, which may be used to turn off immune responses in situations of graft rejection and autoimmune disorders. Furthermore, methods of treating tumors and viruses in humans have been developed.

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