DNA encoding murine-human chimeric antibodies specific for antig

Details DNA encoding murine-human chimeric antibodies specific for antig DNA encoding murine-human chimeric antibodies specific for antig

1992-01-06

1993-07-27

Lacey, David L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4351723, 4353201, 43524027, 4352402, 5303873, 53038825, 536 2353, C12N 120, C12N 510, C12N 1500, C07H 1512

Patent

active

052310264

ABSTRACT:
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B cells but not basophils or the secreted, soluble form of IgE. DNA constructs encoding chimeric antibodies, with murine variable regions and human constant regions, which bind to this epitope, can be produced and expressed in transfected mycloma cells.

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