DNA encoding mitogen activated protein kinase, FRK

Details DNA encoding mitogen activated protein kinase, FRK DNA encoding mitogen activated protein kinase, FRK

1994-09-29

1999-07-20

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

536 232, 4353201, 4352401, 435194, C12N 121, C12N 1563, C12N 510, C07H 2104

Patent

active

059255579

ABSTRACT:
An isolated c-Fos regulating kinase polypeptide (FRK) characterized by having a molecular weight of 88 kD as determined by reducing SDS-PAGE, having threonine and serine kinase activity, phosphorylating the c-Fos activation domain and polynucleotide sequences and method of detection of FRK are provided herein. Also described are methods for identifying compositions which affect FRK activity, thereby affecting c-Fos activation and subsequent activation of genes associated with AP-1 sites.

REFERENCES:
Moller, D.E. et al. (1994) "Human rsk isoforms: cloning and characterization of tissue-specific expression" Amer. J. Physio. 266(2 pt 1):C351-C359, Feb. 1994.
Derijard, B. et al. (1994) "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain" Cell 76:1025-1037, Mar. 1994.
Deng, et al., c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK, Nature, 371:171-175, 1994.
Taylor, et al., Identification of a nerve growth factor-and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-FOS, Proc. Natl. Acad. Sci., USA, 90:368-372, 1993.
Richard A. Lerner, Tapping the immunological repertoire to produce antibodies of predetermined specificity, Nature, 299:592-596, 1982.

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