DNA encoding members of the IL-1 family, IL-1 delta

Details DNA encoding members of the IL-1 family, IL-1 delta DNA encoding members of the IL-1 family, IL-1 delta

1997-09-29

1999-08-31

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 695, 4352523, 4353201, 536 235, C12N 1524, C12N 1500

Patent

active

059453109

ABSTRACT:
IL-1 delta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1 delta peptides are polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e.g. inflammatory bowel disease, psoriasis), transplant rejection, graft versus host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, bone diseases (e.g. osteoporosis), cancer (e.g. lymphoproliferative disorders), atherosclerosis, and Alzheimer's disease, among others, and diagnostic assays for such conditions.

REFERENCES:
Okamura et al, Nature 378, Nov. 1995, pp. 88-91.
Bazan et al Nature 379, Feb. 1996, p. 591.
EST #78362.

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