DNA encoding megakaryocyte growth and development factor analogs

Details DNA encoding megakaryocyte growth and development factor analogs DNA encoding megakaryocyte growth and development factor analogs

1995-02-15

1997-12-09

Ulm, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 695, 435325, 4352523, 4353201, 935 11, 935 27, 935 66, 935 70, C12N 1519, C07K 1452

Patent

active

056962509

ABSTRACT:
MGDF analogs having one or more changed glycosylation sites as compared to a naturally occuring MGDF sequence of a corresponding number of amino acids are disclosed. The invention also relates to DNA sequences encoding said MGDF analogs, recombinant plasmids and host cells for analog expression, and therapeutic compositions including such analogs.

REFERENCES:
patent: 5217881 (1993-06-01), Park
patent: 5218092 (1993-06-01), Sasaki et al.
Lok et al. (1994) Nature vol. 369 pp. 565-568.
Bose et al. (1976) J. of Biol. Chem. vol. 251, No. 6, pp. 1659-1662.
Chang et al. (1995). J. of Biol. Chem. vol. 270, No. 2, pp. 511-514.
Delorme et al. (1992) Biochemistry 31/41:9871-9876.

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