DNA encoding megakaryocyte differentiation factor

Details DNA encoding megakaryocyte differentiation factor DNA encoding megakaryocyte differentiation factor

1995-06-07

1999-02-23

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4353201, 435325, 435348, 435410, 536 235, 800 2, C12P 2106, C12N 1500, C12N 500, C07H 2104

Patent

active

058742530

ABSTRACT:
A novel megakaryocyte differentiation factor, for example, consisting essentially of SEQ ID NO: 30; DNA coding for the megakaryocyte differentiation factor, an expression vector comprising the DNA, a host transformed with the expression vector, and a process for production of the megakaryocyte differentiation factor using the host. The megakaryocyte differentiation factor accelerates differentiation of megakaryocytes in the presence of IL-3, and acts as a thrombopoietin, and therefore an effective medicament to various diseases involving a decrease in platelete.

REFERENCES:
H. Mizoguchi: Tanpakushitsu Kakusan Koso, 36, 1195-1201, 1991.
T. Matsuda et al., Tanpakushitsu Koso, 36, 1184-1194, 1991.
N. Yamaguchi et al.: "Characterization of New Human Pancreatic Cancer Cell Lines Which Propagate in a Protein-free Chemically Defined Medium," Cancer Res., 50, 7008-7014, 1990.
A. Dhar et al, "Platelet-Activating Factor Stimulation of Tyrosine Kinase and Its Relationship to Phospholipase C in Rabbit Platelets: Studies with Genistein and Monoclonal Antibody to Phosphotyrosine", vol. 87, 1990, p. 519-525.
Chemical Abstracts 113: 22039y, vol. 113, 1990.

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