DNA encoding MCK-10, a novel receptor tyrosine kinase

Details DNA encoding MCK-10, a novel receptor tyrosine kinase DNA encoding MCK-10, a novel receptor tyrosine kinase

1993-11-16

2000-04-18

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 435 697, 536 234, 536 235, C12N 510, C12N 1512, C12N 1562

Patent

active

060513977

ABSTRACT:
The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of inhibiting MCK-10 activity. The invention relates to differentially spliced isoforms of MCK-10 and to other members of the MCK-10 receptor tyrosine kinase family. Genetically engineered host cells that express MCK-10 may be used to evaluate and screen drugs involved in MCK-10 activation and regulation. The invention relates to the use of such drugs, in the treatment of disorders, including cancer, by modulating the activity of MCK-10.

REFERENCES:
Johnson et. al, P.N.A.S. 90:5677-5881, Jun. 1993.
Zerlin et al., 1993, NEP: a novel receptor-like tyrosine kinase expressed in proliferating neuroepithelia. Oncogene 8:2731-2739.
Hanks et al., 1988, The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42-52.
Poole et al., 1981, Sequence expression of the discoidin I gene family in Dictyostelium Discoideum. J. Mol. Biol. 153:273-289.

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