DNA encoding MAGE-1 C-terminal cytotoxic t lymphocyte immunogeni

Details DNA encoding MAGE-1 C-terminal cytotoxic t lymphocyte immunogeni DNA encoding MAGE-1 C-terminal cytotoxic t lymphocyte immunogeni

1995-06-05

1998-05-12

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 693, 4352522, 4352523, 4352542, 4353201, 536235, C12N 1563, C12N 1512

Patent

active

057503958

ABSTRACT:
The complete nucleotide and amino acid sequences of the human MAGE-1 antigen are provided. Peptides from residues of the C-terminal are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against MAGE-1 antigens. The peptides are particularly useful in methods for stimulating the immune response of individuals against MAGE-1 antigens associated with melanomas.

REFERENCES:
patent: 5342774 (1994-08-01), Boon et al.
patent: 5405940 (1995-04-01), Boon et al.
patent: 5462871 (1995-10-01), Boon-Falleur et al.
Traversari, C. et al. Immunogenetics 35:142-152, Feb. 1992.
Bowie et al., "Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions," Science, 247:1306-1310 (Mar. 16, 1990).
Herlyn and Koproski, "Melanoma Antigens: Immunological and Biological Characterization and Clinical Significance", Ann. Rev. Immunol. 6: 283-308 (1988).
Van den Eynde et al., "Presence on a human Melanoma of Multiple Antigens Recognized by Autologous CTL", Int. J. Cancer 44:634 (1989).
Deres, "In Vivo Priming of Virus-Specific Cytotoxic T Lymphocytes with Synthetic Lipopeptide Vaccine" Nature 342:561-564 (1989).
Kumar et al., "Amino Acid Variations at a Single Residue in an Autoimmune Peptide Profoundly Affect its Properties: T-cell Activation, Major Histocompatibility Complex Binding, and Ability to Block Experimental Allergic Encephalomyelitis," Proc. Natl. Acad. Sci. USA, 87:1337-1391 (1990).
Van Bleek et al., "Isolation of an Endogenously Processed Immunodominant Viral Peptide from the Class IH-2K.sup.b Molecule", Nature 348:213-216 (1990).
Rotzschke et al. "Isolation and Analysis of Naturally Processed Viral Peptides as Recognized by Cytotoxic T cells" Nature 348:252-254 (1990).
Schumacher et al., "Peptide Selection by MHC Class I Molecules", Nature 350:703-706 (1991).
Falk et al., "Allele-specific Motifs Revealed by Sequencing of Self-peptides Eluted from MHC Molecules", Nature 351:290-296 (1991).
Van der Bruggen et al., "A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma", Science 254: 1643-1647 (1991).
Traversari et al., "A Nonapeptide Encoded by Human Gene MAGE-1 is Recognized on HLA-A1 by Cytolytic T Lymphocytes Directed Against Tumor Antigen MZ2-E", J. Exp. Med. 176: 1453-1457 (1992).
Paul, ed. Fundamental Immunology, 3d., Raven Press, NY, pp. 977-978, 1222-1223 (1993).
Lanzavecchia, "Identifying Strategies for Immune Intervention," Science, 260:937-943 (1993).
Cohen, "Cancer Vaccines Get a Shot in the Arm," Science, 262:841-843 (1993) .

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