DNA encoding lymphocyte chemoattractant factor (LCF) and uses th

Details DNA encoding lymphocyte chemoattractant factor (LCF) and uses th DNA encoding lymphocyte chemoattractant factor (LCF) and uses th

1994-12-13

1998-09-15

Walsh, Stephen

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4351723, 4352401, 4352402, 4352523, 43525233, 43525411, 435325, 536 231, 536 235, C12N 1519, C12N 2100

Patent

active

058077120

ABSTRACT:
Purified DNA encoding lyphocyte chemoattractant factor (LCF) and the recombinant proteins expressed from such DNA are disclosed. In addition, the invention provides methods for suppressing an LCF-CD4 interaction and screening candidate LCF agonists or antagonists. The invention also provides compositions and methods useful for stimulating proliferation of CD4+ T-cells in a mammal.

REFERENCES:
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Cruikshank, et al. (May 24, 1994) "Molecular and Functional Analysis of a Lymphocyte Chemoattractant Factor: Association of Biologic Function with CD4 Expression", Proc. Natl. Acad. Sci. USA 91(11):5109-5113.
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