DNA encoding interleukin-1 receptor antagonist (IL-1ra.beta.)

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 691, 4352523, 4353201, 536 235, 536 243, 536 2433, C12N 1525, C12N 1500

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058637699

ABSTRACT:
IL-1ra beta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1ra beta polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, septicemia, arthritis, inflammatory bowel disease, graft vs. host disease, autoimmunity, stroke, cardiac ischemia, acute respiratory disease syndrome (ARDS), psoriasis, restenosis, traumatic brain injury, AIDS, cachexia., among others, and diagnostic assays for such conditions.

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Auron, et al., "Nucleotide sequence of human monocyte interleukin 1 precursor cDNA", Proc. Natl. Acad. Sci. USA, 81, pp. 7907-7911 (1984).

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