DNA encoding interleukin-1 antagonist

Details DNA encoding interleukin-1 antagonist DNA encoding interleukin-1 antagonist

1997-08-13

1998-11-17

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 711, 435 712, 4351723, 435325, 4352523, 4353201, 536 231, 536 235, 530350, C12N 1512, C07K 1447

Patent

active

058374957

ABSTRACT:
A novel interleukin-1 antagonist active against both IL-1.alpha. and IL-1.beta. and DNA encoding same are described. Antibodies specific for the novel IL-1 antagonist and prophylatic, therapeutic and diagnostic uses of the IL-1 antagonist in pathologies associated with IL-1 production are also described.

REFERENCES:
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C. A. Dinarello et al. "Blocking IL-1: Interleukin 1 receptor anatagonist in vivo and in vitro", Immunology Today, vol. 12, No. 11, 1991, Cambridge GB, pp. 404-410.
N.F. Zander et al. "cDNA cloning and complete primary structure of skeletal muscle phosphorylase kinase (alpha subunit)", Proceedings of the National Academy of Sciences USA, vol. 85, May 1998, Washington US, pp. 2929-2933.
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Haskill et al, cDNA Cloning of an Intracellular Form of the Human Interleukin 1 Receptor Antagonist Associated with Epithelium, Proc. Natl. Acad. Sci., vol. 88 pp. 3681-3685, May 1991.
Hannum, Charles H. et al., "Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor." Nature, vol. 343, pp. 336-340 (Jan. 25, 1990).
Eisenberg, Stephen P. et al., "Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist." Nature, vol. 343, pp. 341-346 (Jan. 25, 1990).
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