DNA encoding immunogenic gpIII glycoprotein of varicella-zoster

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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536 2372, 4352523, 43525231, 43525233, 43525411, 43525421, 4353201, C12N 1538, C12N 510, C12N 119, C12N 121

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053066359

ABSTRACT:
A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. Antibodies directed against peptides imputed from the DNA sequence can react with the glycoprotein, which itself is reactive with neutralizing antibodies. The amino-terminal sequence of the purified glycoprotein is identical to a portion of the amino acid sequence imputed from the DNA sequence. This glycoprotein is useful for the preparation of a vaccine against VZV.

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