DNA encoding IGFBP-4

Details DNA encoding IGFBP-4 DNA encoding IGFBP-4

1993-08-20

1999-12-21

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4352551, 4353201, 435325, 536 235, C12P 2102, C12N 1511

Patent

active

060047755

ABSTRACT:
An insulin-like growth factor binding protein is isolated from rat serum and partially sequenced. Using nucleotide probes based upon the amino terminal sequence of the isolated protein, the complete sequence for the 233-residue rat protein, termed IGFBP-4, is deduced, and the homologous 237-residue sequence of the human protein is separately deduced. These proteins are useful in the inhibition of cell differentiation and/or proliferation requiring IGFs and are particularly useful in combating breast cancers. Antibodies to the proteins may be employed in diagnostic assays, in purification of the protein and in the modulation of bone growth.

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