DNA encoding hybrid streptokinases with plasminogen fibrin bindi

Details DNA encoding hybrid streptokinases with plasminogen fibrin bindi DNA encoding hybrid streptokinases with plasminogen fibrin bindi

1992-05-22

1993-02-16

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Vector, per se

536 232, 536 234, 435216, 435217, 435226, C12N 1500, C12N 968, C12N 970, C12N 1558

Patent

active

051870983

ABSTRACT:
Compositions and methods of the synthesis of hybrid streptokinase with fibrin binding domains based on gene fusion technology. Recombinant DNA methods have been used to fuse gene segments for streptokinase and for fibrin-binding domains and express the fused gene in prokaryotic microorganisms, and the respective expressed protein is subsequently obtained by biotechnologic fermentation for the purpose of use in clinical medicine.

REFERENCES:
patent: 4764469 (1988-08-01), Ferretti et al.
Klessen, C. et al., Mol. Gen. Genet., 212: 295-300, 1988.
Malke, H. et al., PNAS, 81: 3557-61, 1984.
Malke, H. et al., Gene, 34: 357-62, 1985.
Maniatis, T. et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, NY, pp. 1.7-1.8, 1982.
Forsgren et al., FEBS Letters, 213(2): 254-60, 1987.
Ahmed, Gene, 28: 37-43, 1984.

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