DNA ENCODING HUMAN α AND β SUBUNITS OF NEURONAL...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

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C435S069100, C435S320100, C435S352000, C530S350000, C536S023500

Reexamination Certificate

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06936457

ABSTRACT:
Isolated nucleic acid molecules, i.e., DNA or RNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing α and β subunits and recombinant (i.e., isolated or substantially pure) α subunits and β subunits are provided. In addition, cells expressing various multimeric combinations of subunits (i.e., α1, α2α3α4α5α6and/or α7in combination with at least one of an α and β subunit are also provided. A recombinant, non-human cell line expressing the human α7subunit of nAChR is disclosed.

REFERENCES:
patent: 5371188 (1994-12-01), Heinemann et al.
patent: 5837489 (1998-11-01), Elliott et al.
Peng-X et al., Molecular Pharmacology 45(546-554)1994.
Quik-M et al. Journal of Neurochemistry 67(145-154)1996.
Sambrook-J. ed. Molecular Cloning, Cold Spring Harbor Laboratory Press, 1989, pp. 16.3-16.21.
Lukas, R. J., et al., International Union of Pharmacology. XX. . . . Receptors and Their Subunits, Pharmacological Reviews, 1999, vol. 51, No. 2, p. 397-401.
Porter, J. T., et al., Selective Excitation of Subtypes of Neocortical Interneurons by Nicontinic Receptors, The Journal of Neuroscience, Jul. 1, 1999, 19(13) p. 5228-5235.
Quick, M. et al., Modulation of α 7 Nicotinic Receptor-Mediated Calcium Influx by Nicotinic Agonists, Molecular Pharmacology, 51:499-407 (1997).
Ramirez-Latorre, J. et al., Functional Contributions of α5 Subunit to Neuronal Acetylcholine Receptor Channels, NATURE, vol. 380, Mar. 28, 1996, p. 347-351.
Whiting, P.J. and Lindstrom, J.M., “Characterization of Bovine and Human Neuronal Nicotinic Acetylcholine Receptors Using Monoclonal Antibodies”,J. Neurosci., 8(9):3395-3404, (1988).
Grenningloh et al., Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes,EMBO J. 9(3): 771-776 (1990).
Lamar et al., Amplification of genomic sequences identifies a new gene, alpha 6, in the niocotinic acetylcholine receptor gene family,Abstracts 20th Annual Meeting For Society For Neuroscience 16: 681 #285.2 (1990).
Lin et al., Differential fluorescent staining of human chromosomes with daunomycin and adriamycin—the D-bandsScience 190:61-63 (1975).
EMBL Databank, Accession No. X68275 (Sep. 22, 1992), P. Tarroni.
PIR 38 Databank, Accession No. S27274 (Tarroni et al.).
GeneSeq 12 Databank, Accession No. 006086 (WO 90/10648).
George et al., Chapter 12: Current methods in Sequence Comparison and Analysis inMacromolecular Sequencing and Synthesis, Selected Methods and Applications,Alan R. Liss, Inc., pp. 127-149 (1988).
Koyama et al., Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification,Genomics 26:245-253 (1995).

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