Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-09-30
1999-11-23
Duffy, Patricia A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 435 701, 435 711, 435 712, 4352523, 43525411, 4353201, 435325, 536 235, 935 4, 935 6, 935 22, 935 66, C12Q 168, C12P 2106, C12N 1500, C07H 2104
Patent
active
059898186
ABSTRACT:
The invention provides a human rSec6 related vesicle transport protein (HSEC6) and polynucleotides which identify and encode HSEC6. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HSEC6.
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Tellman, J.T. et al., "Molecular Identification of Two Novel Munc-18 Isoforms Expressed in Non-neuronal Tissues" J.Biol.Chem. (1995) 270:5857-5863.
Hata, Y. and Sudhof, T.C. "A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins" J.Biol.Chem. (1995) 270:13022-13028.
Ting, et al., "rSec6 and rSec8, mammalian homologs of yeast proteins essential for secretion" Proc.Natl.Adac.Sci.USA (1995) 92:9613-9617.
Hsu, S. et al., "The Mammalian Brain rsec6/8 Complex" Neuron (1996) 17:1209-1219.
Bunk, Steve "Scientists, Clinicians Optimistic About New Antischizophrenia Drugs" The Scientist (1997) 11:1,5.
Ting, A.E. et al., (GI 1163173), GenBank Sequence Database (Accession U32575), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Karayiorgou, M. et al., "Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11" Proc.Natl.Acad.Sci.USA (1995) 92:7612-7616.
Lachman, H.M. et al., "Linkage Studies Suggest a Possible Locus for Bipolar Disorder Near the Velo-Cardio-Facial Syndrome Region on Chromosome 22" Amer.J.Med.Gene. (1997) 74:121-128.
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Labrie Samuel T.
Streeter David G.
Duffy Patricia A.
Incyte Pharmaceuticals Inc.
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