DNA encoding human plasminogen modified at the cleavage site

Details DNA encoding human plasminogen modified at the cleavage site DNA encoding human plasminogen modified at the cleavage site

1989-12-01

1992-02-11

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435217, 4352523, 435255, 4353201, 536 27, C12N 1557, C12N 1500, C12N 510, C12N 121, C12N 119

Patent

active

050875728

ABSTRACT:
A cleavage-resistant plasminogen molecule is provided that is conveniently produced in recombinant cells by expression of a nucleic acid sequence encoding the plasminogen molecule. Preferably the plasminogen is a sequence variant with a modification in its two-chain cleavage site. The plasminogen molecule may be purified, acylated, complexed with acylated or non-acylated fibrinolytic enzymes, and formulated into pharmaceutical compositions for use in thrombolytic therapy.

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