DNA encoding human follicle stimulating hormone receptor, vector

Details DNA encoding human follicle stimulating hormone receptor, vector DNA encoding human follicle stimulating hormone receptor, vector

1995-06-07

2000-09-19

Spector, Lorraine

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435325, 435361, 4352523, 4353201, 530351, 536 235, 935 9, C12N 1512, C12N 1563, C07K 14705

Patent

active

061210161

ABSTRACT:
The present invent embraces essentially pure human FSH receptor, or a fragment or mutant thereof which binds FSH, DNA encoding said receptor, fragment or mutant, expression vectors comprising said DNA, cells transfected with said expression vectors, and methods of producing said receptor, fragment or mutant by culturing said transfected cells. The present invention also includes pharmaceutical compositions comprising said receptor, fragment or mutant, as well as methods of treating patients with such compositions to reduce endogenous FSH bioactivity. An improved assay for human FSH using the receptor, fragment or mutant of the present invention is also disclosed.

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M. Parmentier et al., Science 246:1620-1622, Dec. 22, 1989.
F. Libert et al., Science 244:569-572, May 5, 1989.
Sprengel, R., et al., Mol. Endocrinol., vol. 4, 525 (1990).
Minegish, T., et al., Biochem. Biophys. Res. Comm., vol.175, 1125 (Mar. 29, 1991).
Reichart, L., Jr., et al., "Biochemical Studies on FSH and Its Receptor", Glycoprotein Hormones, W. Chin and I. Boime, eds., (Serono Symposia USA, 1990).
T. Minegishi et al, J. Endocrinol. 141:369-375, 1994.

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