Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-11
1998-12-15
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 694, 4353201, 435 698, 536 234, 536 2351, 530399, C12N 1515, C12N 1563, C07K 1450
Patent
active
058495380
ABSTRACT:
The present invention is directed to DNA encoding human endothelial cell growth factors, and to plasmids comprising said DNA. In particular, the invention relates to DNA encoding a cleavable signal peptide and an endothelial cell growth factor, wherein removal of said signal peptide yields a mature form of the growth factor.
REFERENCES:
patent: 4394443 (1983-07-01), Weissman et al.
patent: 4401662 (1983-08-01), Lormeau et al.
patent: 4443546 (1984-04-01), Stemerman et al.
patent: 4444760 (1984-04-01), Thomas
patent: 4446314 (1984-05-01), Jordan
patent: 4468464 (1984-08-01), Cohen et al.
patent: 4612367 (1986-09-01), Grinnan et al.
patent: 4658021 (1987-04-01), Goeddel et al.
patent: 4668476 (1987-05-01), Bridgham et al.
patent: 4675285 (1987-06-01), Clark et al.
patent: 4696917 (1987-09-01), Lindstrom et al.
patent: 4788135 (1988-11-01), Davis et al.
patent: 4826827 (1989-05-01), Lormeau et al.
patent: 4882275 (1989-11-01), Klagsbrun
patent: 5032679 (1991-07-01), Brandley et al.
patent: 5348941 (1994-09-01), Middaugh et al.
patent: 5401832 (1995-03-01), Linemeyer et al.
patent: 5439818 (1995-08-01), Fiddes et al.
Brake et al. P.N.A.S. 81:4642-4646, 1984.
Lobb et al., Purification and Characterization of Heparin-binding Endothelial Cell Growth Factors, J. Biol. Chem., 264:4, 1924-1928 (1985).
Lobb et al., Comparison of Human and Bovine Brain Derived Heparin-Binding Growth Factors, Biochemical and Biophysical Research Communications, 131:2, 586-592 (1985).
Bohlen et al., Acidic fibroblast growth factor (FGF) from bovine brain: amino-terminal sequence and comparison with basic FGF, EMBO J., 4, 1951-1956 (1985).
Burgess et al., Multiple Forms of Endothelial Cell Growth Factor-Rapid Isolation and Biological and Chemical Characterization, J. Biol. Chem. 260, 11389-11392 (1985).
, , Collaborative Research Inc., Product Catalog (1983).
, , Collaborative Research Inc. Product Catalog (1986).
Conn et al., The Isolation and Purification of Two Anionic Endothelial Cell Growth Factors from Human Brain, Biochem. Biophys. Res. Comm. 124, 262-268 (1984).
de Ferra et al., Alternative splicing accounts for the four forms of myelin basic protein, Cell 43, 721-727 (1985).
Esch et al., Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF, Proc. Natl. Acad. Sci., USA 82, 6507-6511 (1985).
Esch, Primary Structure of Bovine Brain Acidic Fibroblast Growth Factor ("FGF"), Biochem. Biophys. Res. Comm. 133, 554-562 (1985).
Gimenez-Gallego et al., Brain-Derived Acidic Fibroblast Factor: Complete Amino acid Sequence and Homologies, Science, 230, 1385-1388 (1985).
Hunkapiller et al., High-sensitivity sequencing with a gas-phase sequenator, Meth. Enzymol. 91, 399-413 (1983).
Jaye et al., Isolation of a human-anti-haemophilic factor IX cDNA clone using a unique 52-base synthetic oligonucleotide probe deduced from the amino acid sequence of bovine factor IX, Nucl. Acids Res. 11, 2325-2335 (1983).
Jaye et al., Modulation of the sis Gene Transcript During Endothelial Cell Differentiation in Vitro, Science 228, 882-885 (1985).
Klagsbrun et al., Heparin affinity of anionic and cationic capillary endothelial cell growth factors: Analysis of hypothalamus-derived growth factors and fibroblast growth factors, Proc. Natl. Acad. Sci. USA 82, 805-809 (1985).
Lathe, Synthetic oligonucleotide probes deduced from amino acid sequence data: Theoretcical and practical implications, J. Mol. Biol. 183, 1-12 (1985).
Lobb et al., Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography, Biochemistry 23, 6295-6299 (1984).
Maciag, An endothelial cell growth factor from bovine hypothalamus: Identification and partial charaterization, Proc. Natl. Acad. Sci., USA 76, 5674-5678 (1979).
Maciag, High and Low Molecular Weight Forms of Endothelial Cell Growth Factor, J. Biol. Chem. 257, 5333-5336 (1982).
Maciag, Angiogenesis, Prog. Hemo. Thromb. 7, 167-182 (1984).
Maciag, Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain, Science 225, 932-935 (1984).
Maciag et al., Preparation of endothelial cell factor, Cell Cult. Methods, Mol. Cell. Biol. 1, 195-205 (1984).
Marglin et al., Chemical synthesis of peptides and proteins, Ann. Rev. Biochem. 39, 841-866 (1970).
Metzler, , Biochemistry, Academic Press, Inc. London (1977).
Schreiber et al., Interaction of endothelial cell growth factor with heparin: Characterization by receptor and antibody recognition, Proc. Natl. Acad. Sci. USA 82, 6138-6142 (1985).
Schreiber et al., A unique family of endothelial cell mitogens: The antigenic receptor cross-reactivity of bovine endothelial cell growth factor, brain-derived acidic fibroblast growth factor, and eye-derived growth factor-II, J. Cell. Biol. 101, 1623-1626 (1985).
Thomas, Purification and characterization of acidic fibroblast growth factor from bovine brain, Proc. Natl. Acad. Sci. USA 81, 357-361 (1984).
Thomas et al., Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1, Proc. Natl. Acad. Sci. USA 82, 6409-6413 (1985).
Thomas et al., Fibroblast growth factors: broad spectrum mitogens with potent angiogenic activity, Trends in Biochem Sci. 11, 81-84 (1986).
Watson, Recombination at the Molecular Level, Molecular Biology of the Gene (1987).
, , Webster's II Riverside Univ. Dictionary, p. 444 (1984).
Mestre et al., Comparative Effects of Heparin and PK 10169, A Low Molecular Weight Fraction, In a Canine Model of Arterial Thrombosis, Thrombosis Research, 38, 389-399 (1985).
Alberts et al., The Extracellular Matrix, Molecular Biology of the Cell, Garland Pub., 692-715 (1983).
Burgess Wilson
Drohan William N.
Jaye Michael
Maciag Thomas
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Saoud Christine
Ulm John
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