DNA encoding human cysteine protease

Details DNA encoding human cysteine protease DNA encoding human cysteine protease

1997-09-12

1998-11-24

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4353201, 435325, 43525421, 43525233, 536 232, 536 235, 536 231, C12N 948, C07H 2104

Patent

active

058405623

ABSTRACT:
The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.

REFERENCES:
Merckelbach, A. et al., "cDNA sequences of Schistosoma japonicum coding for two cathepsin B-like proteins and Sj32", Trop. Med. Parasitol., 45: 193-198 (1994).
Bouillaud, F., EST Database Accession No. R17110.
Azaryan, A.V. and Vivian Y.H. Hook, "Distinct Properties of Prohormone Thiol Protease (PTP) Compared to Cathespins B, L, and H: Evidence for PTP as a Novel Cysteine Protease", Arch. Biochem. Biophys., 314: 171-177 (1994).
Schiller, M.R. et al., "`Prohormone Thiol Protease` (PTP) Processing of Recombinant Proenkephalin", Biochemistry, 34: 7988-7995 (1995).
Okubu, K. et al., EMBL Database, Entry HS000S394, Accession No. D12242.
Hillier, L. et al., EMBL Database, Entry HS824135, Accession No. R66824.
Merckelbach et al., Trop. Med. Parasit., vol. 45, pp. 193-198, 1994.

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