DNA encoding human calcium channel .alpha.-.sub.1A, .beta..sub.1

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 235, 435 691, 435325, 43525411, 435 4, 514 44, C12N 1512, C12Q 102, C07K 14705

Patent

active

058742360

ABSTRACT:
Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.-and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

REFERENCES:
patent: 4788135 (1988-11-01), Davis et al.
patent: 4912202 (1990-03-01), Campbell et al.
patent: 4954436 (1990-09-01), Froehner et al.
patent: 5024939 (1991-06-01), Gorman
patent: 5051403 (1991-09-01), Mijanich et al.
patent: 5189020 (1993-02-01), Mijanich et al.
patent: 5264371 (1993-11-01), Mijanich et al.
patent: 5424218 (1995-06-01), Mijanich et al.
Powers, et al., "Assignment of the human gene for the .alpha..sub.1 subunit of the cardiac DHP-sensitive Ca.sup.2+ channel (CCHL1A1) to Chromosome 12p12-pter," Genomics, 10: 835-839 (1991).
Kim, et al., "IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channels," Science, 239: 405-408 (1988).
Claudio, et al., "Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts," Science, 238: 1688-1694 (1987).
Tanabe, et al., "Primary structure of the receptor for calcium channel blockers from skeletal muscle," Nature, 328:313-318 (1987).
Nakayama, et al., "Purification of a putative Ca.sup.2+ channel protein from rabbit skeletal muscle," J.Biol.Chem., 262:6572-6576 (1987).
Vaghy, et al., "Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations," J.Biol.Chem., 262(29): 14337-14342 (1987).
Leung, et al., "Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca.sup.2+ channel from rabbit skeletal muscle," J.Biol.Chem., 262(17): 7943-7946 (1987).
Sharp, et al., "Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor," J.Biol.Chem., 62(25): 12309-12315 (1987).
Takahashi, et al., "Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle," Proc.Natl.Acad.Sci. (USA), 84: 5478-5482 (1987).
Morton et al. "Monoclonal antibody identifies a 200-kDA subunit of the dihydropyridine-sensitive calcium channel," J.Biol.Chem., 262(25): 11904-11907 (1987).
Barhanin, et al., "The calcium channel antagonists receptor from rabbit skeletal muscle: reconstitution after purification and subunit characterization," Eur.J.Biochem., 164: 525-531 (1987).
Sieber, et al., "The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel," Eur.J.Biochem., 167: 117-122 (1987).
Lang, et al., "The effect of myasthenic syndrome antibody on presynaptic calcium channels in the mouse," J.Physiol., 390: 257-270 (1987).
Curran and Morgan, "Barium modules c-fos expression and post-translational modification," Proc.Natl.Acad.Sci., 83: 3521-8524 (1986).
Fisch, et al., "c-fos sequences necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate, and the calcium inophore," Mol.Cell.Biol., 7(10): 3490-3502 (1987).
Noda, et al., "Existence of distinct sodium channel messenger RNAs in rat brain," Nature, 320: 188-192 (1986).
Noda, et al., "Expression of functional sodium channels from cloned cDNA," Nature, 322: 826-828 (1986).
Mierendorf, et al., "Gene isolation by screening kgtll libraries with antibodies," Methods in Enz., 152: 458-469 (1986).
Gustin, et al., "Ion channels in yeast," Science, 233: 1195-1197 (1986).
Striessnig, et al., "Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel," FEBS Letters, 212(2):247-253 (1987).
Froehner, "New insights into the molecular structure of the dihydropyridine-sensitive calcium channel," TINS, 11(3): 90-92 (1988).
Catterall, et al., "Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle," J.Biol.Chem., 263(8): 3535-3538 (1988).
Curtis, et al., "Purification fo the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules," Biochemistry, 23(10): 2113-2118 (1984).
Borsotto, et al., "The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca.sup.2+ channel," J.Biol.Chem., 260(26): 14255-14263 (1985).
Cooper, et al., "Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue," J.Biol.Chem., 262(2): 509-512 (1987).
Wood, "Gene cloning based on long oligonucleotide probes," Methods in Enzymology, 152: 443-447 (1987).
Schmid, et al., "Immunochemical analysis of subunit structure of 1,4-dihydropyridine receptors associated with voltage-dependent Ca.sup.2+ channels in skeletal, cardiac, and smooth muscles," Biochemistry, 25:3492-3495 (1986).
Mishina, et al., "Location of functional regions of acetylcholine receptor .alpha.-subunit by site-directed mutagenesis," Nature, 313: 364-369 (1985).
Hamill, et al., "Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches," Pfluger Archiv.European Journal of Physiology, 391: 85-100 (1981).
Hess, et al., "Different modes of Ca channel gating behavior favored by dihydropyridine Ca agonist and antagonists," Nature, 311: 538-544 (1984).
Leung, et al., "Biochemical and ultrastructural characterization of the 1,4-dihydropyridine receptor from rabbit skeletal muscle," J. of Biol.Chem., 263(2): 994-1001 (1988).
Imagawa, et al., "Phosphorylation of the 1,4-dihydropyridine receptor of the voltage-dependent Ca.sup.2+ channel by an intrinsic protein kinase in isolated triads from rabbit skeletal muscle," J. of Biol.Chem., 262(17): 8333-8339 (1987).
Miller, "Multiple calcium channels and neuronal function," Science, 235: 46-52 (1987).
Kozak, "An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs," Nucleic Acids Research, 15(20): 8125-8148 (1987).
Von Heijne, "Signal sequences: the limits of variation," Jour. of Mol.Biol., 184: 99-105 (1985).
Hubbard, et al., "Synthesis and processing of asparagine-linked oligosaccharides.sup.1,2," Ann.Rev.Biochem., 50:555-583 (1981).
Feramisco, et al., "Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase," Journal of Biological Chemistry, 255(9): 4240-4245 (1980).
Takahashi, et al., "Identification of an .alpha. subunit of dihydropyridine-sensitive brain calcium channels," Science, 236: 88-91 (1987).
Hofmann, et al., "Regulation of the L-type calcium channel," TINS, 8: 393-398 (1987).
Curtis, et al., "Reconstitution of the voltage-sensitive calcium channel purified from skeletal muscle transverse tubules," Biochemistry, 25: 3077-3083 (1986).
Smith, et al., "Calcium channel activity in a purified dihydropyridine-receptor preparation of skeletal muscle," Biochemistry, 26: 7182-7188 (1987).
Meshi, et al., "Nucleotide sequence of the 30K protein cistron of cowpea strain of tobacco mosaic virus," Nucleic Acids Research, 10(19): 6111-6117 (1982).
Nikaido, et al., "Molecular cloning of cDNA encoding human interleukin-2 receptor," Nature, 311: 631-636 (1984).
Roberts, et al., "Paraneoplastic myasthenic syndrome IgG inhibits .sup.45 Ca.sup.2+ flux in a human small cell carcinoma line," Nature, 317: 737-739 (1985).
Starr, et al., "Primary structure of a calcium channel that is highly expressed in rat cerebellum, " Proc.Natl.Acad.Sci. USA, 88: 5621-5625 (1991).
Snutch, et al., "Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS," Neuron, 7: 45-57 (1991).
Hui, et al., "Molecular cloning of multiple sybtypes of a novel rat brain isoform of the a.sub.1 subunit of the voltage-dependent calcium channel," Neuron, 7: 35-44 (1991).
Bean et al., "Classes of calcium channels in vertebrate cells," Annu.Rev. Physiol., 51: 367-384 (1989).
Swandulla, et al., "Do calcium channel classifications account for neuronal calcium channel diversity?" T

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

DNA encoding human calcium channel .alpha.-.sub.1A, .beta..sub.1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA encoding human calcium channel .alpha.-.sub.1A, .beta..sub.1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding human calcium channel .alpha.-.sub.1A, .beta..sub.1 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-305595

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.