DNA encoding human asthma associated factor 1

Details DNA encoding human asthma associated factor 1 DNA encoding human asthma associated factor 1

1996-08-23

2000-03-14

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 712, 4351723, 435325, 4352523, 43525233, 43525234, 4352535, 4352542, 43525421, 43525422, 43525423, 4352555, 4352556, 4353201, 536 235, 530350, 514 44, C12N 1524, C12N 1563, C07K 1454

Patent

active

060371498

ABSTRACT:
A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1. When this substitution occurs in both alleles in one individual, it is associated with less evidence of atopic allergy including asthma, fewer abnormal skin test responses, and a lower serum total IgE. Thus, applicant has identified the existence of a non-asthmatic, non-atopic phenotype characterized by methionine at codon 117 when it occurs in both AAF1 gene products in one individual.

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