Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-11-04
1996-09-17
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 4352402, 4353201, 514 2, 530350, C12Q 100, C12P 2106, A61K 3800, C07K 100
Patent
active
055567533
ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a human .alpha..sub.1a adrenergic receptor, an isolated nucleic acid molecule encoding a human .alpha..sub.1b adrenergic receptor and an isolated nucleic acid molecule encoding a human .alpha..sub.1c adrenergic receptor, an isolated protein which is a human .alpha..sub.1a adrenergic receptor, an isolated protein which is .alpha..sub.1b adrenergic receptor and a isolated protein which is a human .alpha..sub.1c adrenergic receptor, vectors comprising an isolated nucleic acid molecule encoding a human .alpha..sub.1a adrenergic receptor, vectors comprising an isolated nucleic acid molecule encoding a human .alpha..sub.1b adrenergic receptor, and vectors comprising an isolated nucleic acid molecule encoding a human .alpha..sub.1c adrenergic receptor, mammalian cells comprising such vectors, antibodies directed to the human .alpha..sub.1a adrenergic receptor, antibodies directed to the human .alpha..sub.1b adrenergic receptor, and antibodies directed to the human .alpha..sub.1c adrenergic receptor, nucleic acid probes useful for detecting nucleic acid encoding a human .alpha..sub.1a adrenergic receptor, nucleic acid probes useful for detecting nucleic acid encoding a human .alpha..sub.1b adrenergic receptor, and nucleic acid probes useful for detecting nucleic acid encoding a human .alpha..sub.1c adrenergic receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human .alpha..sub.1a adrenergic receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human .alpha..sub.1b adrenergic receptor, and antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human .alpha..sub.1c adrenergic receptor, pharmaceutical compounds related to the human .alpha..sub.1a adrenergic receptor, pharmaceutical compounds related to the human .alpha..sub.1b adrenergic receptors, and pharmaceutical compounds related to the human .alpha..sub.1c adrenergic receptors, and nonhuman transgenic animals which express DNA encoding a normal or a mutant human .alpha..sub.1a adrenergic receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian human .alpha..sub.1b adrenergic receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian human .alpha..sub.1c adrenergic receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with human .alpha..sub.1a, .alpha..sub.1b and .alpha..sub.1c adrenergic receptors.
REFERENCES:
Bruno et al "Molecular Cloning . . . " BBRC 179: 1485-1490 Sep. 30, 1991.
Lomasney et al "Molecular Cloning . . . " JBC 266: 6365-6369 Apr. 5, 1991.
Voigt et al. "Sequence of a rat brain . . . " NAR 18: 1053 1990.
Schwinn et al. "Molecular Cloning . . . " JBC 265: 8183-8189 May 15, 1990.
Bard Jonathan A.
Forray Carlos
Weinshank Richard L.
Kim Hyosuk
Synaptic Pharmaceutical Corporation
Wax Robert A.
White John P.
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