Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1988-11-30
1993-06-29
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352523, 43525233, 435255, 435256, 4353201, 536 232, C12N 510, C12N 121, C12N 119, C12N 1512
Patent
active
052234258
ABSTRACT:
The invention provides a recombinant purified human protein in substantial quantities which has both adipsin and complement D activity. The invention also provides materials and methods to produce the protein. In addition, antibodies immunoreactive with this protein are useful to diagnose metabolic defects attributable to adipsin deficiency or complement D deficiency. The protein can be used to treat obesity caused by adipsin deficiency or to treat subjects for infection.
REFERENCES:
Min et al. 1986 Nucleic Acids Research 14:8879.
Cook et al. 1985. Proc. Natl. Acad. Sci USA 82:6480.
Spiegelmane et al 1983 J. Biol. Chem. vol. 258:10083.
Suggs et al Proc. Natl. Acad. Sci. USA 78:6613 Use of Synthetic Oligonucleotides.
Naniatis et al. 1982 Cold Spring Harbor Lab., Molecular Cloning: A Lab. Manual.
Niemann et al., Biochemistry 23:2482 1984.
Flier Jeffrey S.
Rosen Barry M.
Spiegelman Bruce M.
White R. Tyler
Le Guyader J.
Schwartz Richard A.
The Beth Israel Hospital Association
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