Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-12-17
2000-01-11
Huff, Sheela
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 536 235, 530324, 530350, C12P 2106, C12N 1500, C07H 2104, A61K 3800
Patent
active
060134712
ABSTRACT:
Isolated nucleic acid molecules encoding variant hK2 polypeptides and fragments thereof, as well as expression cassettes and host cells comprising said nucleic acid molecules, are provided. Also provided is a method to express a nucleic acid molecule encoding a variant hK2 polypeptide.
REFERENCES:
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3842067 (1974-10-01), Sarantakis
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3862925 (1975-01-01), Sarantakis et al.
patent: 3901654 (1975-08-01), Gross
patent: 3935074 (1976-01-01), Rubenstein et al.
patent: 3972859 (1976-08-01), Fujino et al.
patent: 3984533 (1976-10-01), Uzgiris
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4034074 (1977-07-01), Miles
patent: 4092408 (1978-05-01), Litt
patent: 4098876 (1978-07-01), Piasio et al.
patent: 4105602 (1978-08-01), Colescott et al.
patent: 4353982 (1982-10-01), Gomez et al.
patent: 4371515 (1983-02-01), Chu
patent: 4446122 (1984-05-01), Chu et al.
patent: 4487715 (1984-12-01), Nitecki et al.
patent: 4629783 (1986-12-01), Cosand et al.
patent: 4757048 (1988-07-01), Lewicki et al.
patent: 4792528 (1988-12-01), Canfield et al.
patent: 5516639 (1996-05-01), Tindall et al.
P Altman, et al., "Inbred and Genetically Defined Strains of Laboratory Animals", Biological Handbooks, III, Federation of American Societies for Experimental Biology, pp. 21-29, (1992).
P. Andrews, et al., "Tumor-promoting Phorbol Ester Down-Regulates the Androgen Induction of Prostate-specific Antigen in a Human Prostatic Adenocarcinoma Cell Line", Cancer Research, 52, 1525-1529, (Mar., 1992).
A. Angermann, et al., "Purifications and characterizations of human salivary-gland prokallikrein from recombinant baculovirus-infected insect cells", Eur. J. Biochem., 206, 225-233, (1992).
A. Baker, et al., "Human Kidney Kallikrein: cDNA Cloning and Sequence Analysis", DNA, 4, 445-450, (1985).
T. Berg, et al., "A Common Nomenclature for Members of the Tissue (Glandular) Kallikrein Gene Families", Recent Progress on Kinins, Birkhauser Verlag, Basel, 19-25, (1992).
L. Carpino, et al., "The 9-Fluorenylmethoxycarbonyl Amino-Protecting Group", J. Org. Chem., 37, 3404-3409, (1972).
C. Chang, et al., "Solid-phase peptide synthesis using mild base cleavage of Na-fluorenylmethyloxycarbonlyamino acids, exemplified by a synthesis of dihydrosomatostatin", Int. J. Pept. Pro. Res., 11, 246-249, (1978).
P. Chapdelaine, et al., "High Level Expression in the Prostate of a Human Glandular Kallikrein mRNA Related to Prostate-Specific Antigen", FEBS Lett., 236, 205-208, (Aug., 1988).
J. Clements, "The Glandular Kallikrein Family of Enzymes: Tissue-Specific Expression and Hormonal Regulation", Endocr. Rev., 10, 393-419, (1989).
P. Cohen, et al., "Biological Effects of PS as an IGFBP-3 Protease", In: Program and Abstracts, 74th Annual Meeting of the Endocrine Society, San Antonio, TX, p. 291, Abstract No. 960, ((Jun. 24-27, 1992)).
M. Digby, et al., "Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene", Nuc. Acids Res., 17, 2137, (1989).
B. Evans, et al., "Structure and Chromosomal Localization of the Human Renal kallikrein Gene", Biochemistry, 27, 3124-3129, (1988).
D. Fukusima, et al., "Nucleotide Sequence of Cloned cDNA for Human Pancreatic Kallikrein", Biochemistry, 24, 8037, (1985).
Pirkko Henttu, et al., "cDNA Coding for the Entire Human prostate Specific Antigen Shows High Homologies to the Human Tissue Kallikrein Genes", Biochemical and Biophysical Research Communications, 160, 903-910 (Apr. 28, 1989).
P. Henttu, et al., "Expression of the Gene Coding for Human Prostate-Specific Antigen and Related hGK-1 in Benign and Malignant Tumors of the Human Prostate", Int. J. Cancer, 45, 654-660, (1990).
C S Hill, et al., "The preparation of Monoclonal Antibodies Which React Preferentially with Human Bone Alkaline Phosphatase and not Liver Alkaline Phosphatase", Clinica Chemica Acta, 186, 315-320, (1989).
C. Killian, et al., "Mitogenic Response of Osteoblast Cells to Prostate-Specific Antigen Suggests an Activation of Latent TGF-6 and a Proteolytic Modulation of Cell Adhesive Receptors", Biochem. Biophys. Res. Comm., 192, 940, (1993).
K. Kuus-reichel, et al., "Production of IgG Monoclonal Antibodes to the Tumor Associated Antigen, CA-195", Hybridoma, 13, pp. 31-36 (1994).
U. K. Laemmli, "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4", Nature, 227, 680-685, (Aug., 1970).
M. Lebeau, et al., "Report of the committee on the genetic constitution of chromosomes 18 and 19", Cytogenet. Cell Genet., 51, 338-357, (1989).
F. Lottspeich, et al., "N-Terminal Amino Acid Sequence of Human Urinary Kallikrein Homology with Other Serine Proteases", Hoppe-Seyler's Z. Physiol. Chem., 360, 1947-1950, (Dec., 1979).
H. Lu, et al., "Human Urinary Kallikrein", Int. J. Peptide Protein Res., 33, 237-249, (1989).
V. A. Luckow, et al., "Trends in the Development of Baculovirus Expression Vectors", Bio/Technology, 6, pp. 47-55, (Jan. 1988).
A. Lundwall, "Characterization of the gene for Prostate-specific antigen, a human glandular kallikrein", Biochem. Biophys. Research Comm., 161, 1151-1159, (Jun., 1989).
A. Lundwall, et al., "Molecular cloning of human prostate specific antigen cDNA", FEBS Lett., 214, 317-322, (Apr., 1987).
R. McCormack, et al., "Molecular Forms of Prostate-Specific Antigen and the Human Kallikrein Gene Family: A New Era", Urology, 45, 729-744, (May 1995).
R. Merrifield, "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide", J. Am. Chem. Soc., 85, 2149-2154, (Jul., 1963).
B. Montgomery, et al., "Hormonal Regulation of Prostate-Specific Antigen (PSA) Glycoprotein in the Human Prostatic Adenocarcinoma Cell Line, LNCaP", The Prostate, 21, 63-73, (1992).
B. Morris, "hGK-1: A Kallikrein Gene Expressed in Human Prostate", Clin. Exp. Pharmacol. Physiol, 16, 345-351, (1989).
P. Murtha, et al., "Androgen Induction of a Human Prostate-Specific Kallikrein hKLK2: Characterization of an Androgen Response Element int he 5' Promoter Region of the Gene", Biochemistry, 32, 6459-6464, (1993).
G. Paradis, et al., "Looking for Human Glandular Kallikrein-1 in the Prostate", The Prostate, 15, 343-353, (1989).
S. Qui, et al., "In Situ Hybridization of Prostate-Specific Antigen mRNA in Human Prostate", J. Urology, 144, 1550-1556, (1990).
J. P. Ransom, "Practical Competitive Binding Assay Methods;", The C. V. Mosby Company, St. Louis, 1-9, 54-61, (1976).
P. Riegman, et al., "Characterization of the Prostate-Specific Antigen Gene: A Novel Human Kallikrein-Like Gene", Biochem. Biophys. Res. Comm., 159, 95-102, (Feb., 1989).
P. Riegman, et al., "Identification and Androgen-Regulated Expression of Two Major Human Glandular Kallikrein-1 (hKG-+) mRNA Species", Mol. Cell. Endocrinol., 76, 181-190, (1991).
P. Riegman, et al., "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19", FEBS Lett., 247, 123-126, (Apr., 1989).
H. Ropers, et al., "Report of the committee on the genetic constitution of chromosome 19", Cytogenet. Cell Genet., 55, 218-228, (1990).
A. Rosenberg, et al., "Vectors for selective expression of cloned DNAs by T7 RNA polymerase", Gene, 56, 125-135, (1987).
M. S. Saedi, et al., "Overexpression of a human prostate-specific glandular kallikrein hK2, in E. coli and generation of antibodies", Molecular and Cellular Endocrinology, 109, 237-241, (Feb., 1995).
L. J. Schedlich, et al., "Kallikrein Genes: Cloning in Man and Expression in Rat Renal Hypertension", Journal of Hypertension Supplement, 6, S395-S398, (Dec., 1988).
L. Schedlich, et al., "Primary Structure of a Human Glandular Kallikrein Gene", DNA, 6, 429-437, (1987).
L. J. Schedlich, et al., "Three Alu Repeated Sequences Associated with a Human Glandular Kallikrein Gene", Clin. Exper. Pharmacology & Physiology, 15, 339-344, (1988).
P. Schulz, et al., "Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence", Nuc. Acids Res., 16, 6226, (1988).
C. Scorer, et al., "Rapid Selection Using G4
Kumar Abhay
Saedi Mohammad Saeed
Tindall Donald J.
Young Charles Y. F.
Eyler Yvonne
Huff Sheela
Hybritech Incorporated
Mayo Foundation for Medical Education and Research
LandOfFree
DNA encoding hK2 variant polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA encoding hK2 variant polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding hK2 variant polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1461326