DNA encoding heptaprenyl diphosphate synthetase

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing organic compound containing a metal or atom other...

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435 691, 4351723, 435193, 4352523, 43525233, 4353201, 435832, 536 232, C12P 900, C12P 2106, C12N 910, C07H 2104

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057732655

ABSTRACT:
Heptaprenyl diphosphate (HDP)-synthetase derived from Bacillus stearothermophilus which enzymes have the amino acid sequences shown as SEQ ID NOs: 1 to 3; 1 and 2; 2 and 3; or 1 and 3, DNA encoding them, and a method of producing the enzymes.
According to the invention it is possible to industrially produce HDP-synthesizing enzyme and HPD.

REFERENCES:
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Proc. Natl. Acad. Sci. USA, pp. 6761-6764 (1992).
FEBS Lett. 161, pp. 257-260 (1983).
Summary of 67th Meeting of Japanese Biochemical Society No. 1728 (1994) (English Translation).
Summary of 17th Meeting of Japanese Molecular Biology Society (1994) (English Translation).
J. Biochem., 113:3, pp. 355-363, Mar. 1993, Tokyo JP, "Thermostable Farnesyl Diphosphate Synthase . . . Overproduction and Purification", T. Koyama, et al. (Abstract).
FEBS Letters, 161:2, pp. 257-260, Sep. 19, 1983, Amsterdam NL, "Essential Protein Factors for Polyprenyl Pyrophosphase Synthetases . . . ", H. Fuji, et al.
J. Biochem., 270:31, pp. 18396-18400, Aug. 1995, Maryland US, "Molecular Cloning and Nucleotide Sequences . . . Heptaprenyl Diphosphate Synthesis", A. Koike-Takeshita, et al.
Koyama et al. (1994) Tennen Yuki Kagobutsu Toronkai Koen Yoshishu, 36th, 167-174 (abstract).

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