DNA encoding Helicobacter pylori recombinase

Details DNA encoding Helicobacter pylori recombinase DNA encoding Helicobacter pylori recombinase

1994-03-21

1995-07-18

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4352521, 435822, 4352523, C07H 2104

Patent

active

054342538

ABSTRACT:
An isolated nucleic acid encoding the Helicobacter pylori recombinase comprising the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:1 is provided. Also provided is an isolated nucleic acid that selectively hybridizes with the nucleic acid of claim 1 under stringent conditions and has at least 70% complementarity with the segment of the nucleic acid of SEQ ID NO:1 to which it hybridizes. Also provided is a mutant strain of H. pylori that does not express a functional recombinase (recA.sup.- mutant). An immunogenic amount of the recA.sup.- mutant H. pylori in a pharmaceutically acceptable carrier is provided. A method of immunizing a subject against infection by H. pylori comprises administering to the subject an immunogenic amount of mutant H. pylori in a carrier for the mutant.

REFERENCES:
Story et al. Science 259: 1892-1896, 1993.
Roca and Cox Crit. Rev. Biochem. Mol. Biol. 25:415-56, 1990.
Labigne-Roussel et al. J. Bacteriol. 170(4):1704-1708, 1988.
Perez-Perez and Blaser Infect. Immun. 55(5):1256-1263, 1987.
Keener, S. L., McNamee, K. P., McEntee, K. (1984) "Cloning and Characterization of recA Genes from Proteus vulgaris, Erwinia carotovora, Shigella flexner:, and Escherichia coli B/r " J. Bact., 160(1)153-160.

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