DNA encoding galanin receptor activating peptide

Details DNA encoding galanin receptor activating peptide DNA encoding galanin receptor activating peptide

2008-05-20

2008-05-20

Pak, Michael (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C536S023500

Reexamination Certificate

active

07374910

ABSTRACT:
The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

REFERENCES:
patent: 5576296 (1996-11-01), Bartfai et al.
patent: WO 92/12997 (1992-08-01), None
patent: WO 92/20709 (1992-11-01), None
N. Chartel, et al., “Frog Vasoactive Intestinal Polypeptide and Galanin: Primary Structures and Effects on Pituitary Adenylate Cyclase”, Endocrinology, 136(7): 3079-3086(1995).
A. Norberg, et al., Chemical Detection of Natural Peptides by Specific Structures, Federation of European Biochemical Societies, 288(1,2): 151-153(1991).
K. Tatemoto, et al., “Galanin—A Novel Biologically Active Peptide from Porcine Intestine”, Federal of European Biochemical Societies, 164(1): 124-128(1983).
A. Rokaeus, et al., “Construction of a Porcine Adrenal Medullary cDNA Library and Nucleotide Sequence Analysis of Two Clones Encoding a Galanin Precursor”, Proc. Natl. Acad. Sci. USA, 83: 6287-6291(1986).
R. Sillard, et al., “Variant Forms of Galanin Isolated From Porcine Brain”, Peptides, 13: 1055-1060(1992).
K. Smith, et al., “Expression Cloning of a Rat Hypothalamic Galanin Receptor Coupled to Phosphoinositide Turnover”, The Journal of Biological Chemistry, 272(39): 24612-24616(1997).
S. Wang, et al., “Cloning and Expressional Characterization of a Novel Galanin Receptor”, The Journal of Biological Chemistry, 272(51): 31949-31952(1997).
K. Smith, et al., “Cloned Human and Rat Galanin GALR3 Receptors”, The Journal of Biological Chemistry, 273(36): 23321-23326(1998).
Pooga, et al., “Novel Galanin Receptor Ligands”, Journal of Peptide Research 51(1): 65-74(1998).

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