Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1991-11-08
1996-08-13
Walsh, Stephen G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 235, 530385, C12N 1512, C07K 14805
Patent
active
055457274
ABSTRACT:
The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained.
DNA encoding alpha globin fusion proteins is provided.
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Hoffman Stephen J.
Looker Douglas L.
Nagai Kiyoshi
Cooper Iver P.
Somatogen, Inc.
Walsh Stephen G.
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