DNA encoding fused alpha-beta globin pseuodimer and production o

Details DNA encoding fused alpha-beta globin pseuodimer and production o DNA encoding fused alpha-beta globin pseuodimer and production o

1995-05-19

1998-09-01

Carlson, Karen C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 435 691, 530385, 536 234, C12P 2106, C07H 1700, C07K 14805

Patent

active

058010190

ABSTRACT:
The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained.

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