Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-01-15
1993-06-08
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530350, 5303881, C07H 2102
Patent
active
052181006
ABSTRACT:
The present invention relates to the precursor protein of amyloid plaque core (APC) polypeptide, to fragments of the precursor protein and to the diagnostic use of the precursor protein and of the fragments. Furthermore, the invention relates to the DNA coding for the precursor protein, to fragments of this DNA and to the diagnostic use of the DNA and of the fragments.
REFERENCES:
patent: 4666829 (1987-05-01), Glenner et al.
Science, vol. 235, Feb. 1987, pp. 877-880; D. Goldgaber, et al., "Characterization and chromosomal localization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides".
Proc. Natl. Acad. Sci. USA, vol. 83, Apr. 1986, pp. 2662-2666; A. Roher et al.: "Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein".
Proc. Natl. Acad. Sci. USA, vol. 82, Jun. 1985, pp. 4245-4249; C. L. Masters et al.: "Amyloid plaque core protein in Alzheimer disease and Down Syndrome".
Chemical Abstracts, vol. 104, 1986 p. 506, paragraph No. 127641f, Columbus, Ohio, US; C. L. Masters et al.: "Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels", & EMBO J. 1985 4(11), 2757-2763.
Proc. Natl. Acad. Sci. USA, vol. 84, Jun. 1987, pp. 4190-4194; N. K. Robakis et al.: "Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides".
Kang et al., "The Precursor of Alzheimer's Disease Amyloid A4 Protein Resembles a Cell-Surface Receptor," Nature, 325, 733-736 (1987).
Lemaire et al., "The Pre A 4.sub.695 Precursor Protein of Alzheimer's Disease A4 Amyloid is Encoded by 16 Exons," Nucleic Acids Research, 17(2), 517-522 (1989).
Vitek et al., "Absence of Mutation in the Beta-amyloid cDNA's Cloned From the Brains of Three Patients with Sporadic Alzheimer's Disease," Mol. Brain Res., 4, 121-131 (1988); Swiss Prot data base accession number is "B30320,".
Kang Jie
LeMaire Hans-Georg
Muller-Hill Benno
Unterbeck Axel
Bayer Aktiengesellschaft
Brown Johnnie R.
Crane L. Eric
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