Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1992-05-27
1993-06-29
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 691, 4353201, 536 235, C07H 2100
Patent
active
052236110
ABSTRACT:
Human gp130 protein having at least the following properties: (1) the protein has an affinity with a complex of IL-6 (interleukin-6) and an IL-6 receptor (interleukin-6 receptor); (2) the protein shows an apparent molecular weight of 130 kDa in SDS-polyacrylamide electrophoresis; and (3) the protein participates in the transmission of IL-6 signal; DNA coding for the protein, an expression plamid containing the DNA; and a process for production of the protein using the expression plasmid.
REFERENCES:
Schwabe et al. Lympokine Res. 9(4):550 (1990).
Schwabe et al. Progess in Leukocyte Biol. 10A (1989).
Kishimoto, "The Biology of Interleukin-6," Blood, 74:1-10, (1989).
Kishimoto, "Molecular Regulation of B Lymphocyte Resonse," Ann. Rev. Immunol., 6:485-512, (1988).
Hibi et al., "Characterization and Molecular Cloning of Interleukin-6 Receptor (IL-6R)-Associated Signal Transducer," Faseb, (Feb. Am. Soc. Exp. Biol.), 4(7):A1918, Abstract No. 1311, (Apr. 26, 1990).
Taga et al., "Interleukin-6 Triggers The Association of its Receptor With A Possible Signal Transducer, gp130," Cell, 56(3):573-581, (1989).
Short et al., "A Zap a Bacteriophage .delta. Expression Vector With In Vivo Excision Properties," Nucleic Acids Research, 16(15):7583-7600, (1988).
Cold Spring Harbor Syposia On Quantitative Biology, 54(2):713-722, (CSH Laboratory Press, 1989).
Young et al., "Efficient Isolation of Genes by Using Antibody Probes," Proc. Natl. Acad. Sci USA, 80:1194-1198, (1983).
Guest Shelly J.
Hill Jr. Robert J.
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