DNA encoding daunorubicin 14-hyroxylase and method for preparing

Details DNA encoding daunorubicin 14-hyroxylase and method for preparing DNA encoding daunorubicin 14-hyroxylase and method for preparing

1995-02-27

1997-12-09

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 691, 435 717, 4352401, 536 232, C12P 1956, C12P 2104, C12P 2106, C07H 1700

Patent

active

056959664

ABSTRACT:
The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.

REFERENCES:
Columbo et al. 1992 J Bacteriol 174(5): 1641-1646.
Otten et al 1995 J Bacteriol 177(22):6688-6692.
Otten et al 1990 J Bacteriol 172(6): 3427-3434.

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