DNA encoding cytokines that bind the cell surface receptor hek

Details DNA encoding cytokines that bind the cell surface receptor hek DNA encoding cytokines that bind the cell surface receptor hek

1994-05-09

1996-05-14

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 911, 4351723, 4352523, 4353201, 530350, 536 235, C12N 1519, C07K 1452

Patent

active

055166580

ABSTRACT:
Hek ligand (hek-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing hek-L polypeptides. The hek-L polypeptides bind to a cell surface receptor (hek) that is a member of the receptor tyrosine kinase family. Hek is expressed on cells that include certain tumor cell lines. The hek-L polypeptides also bind a distinct receptor tyrosine kinase known elk.

REFERENCES:
patent: 5185483 (1993-02-01), Lemischka
Cerretti et al., "Isolation of cDNAs that Encode Ligands to the Receptor Tyrosine Kinases Hek and Elk; Emergence of a Family of Proteins that are Ligands for the Eph Related Kinases (LERKS)", Abstract for American Assoc. for Cancer Research conference on Growth Factors, Development, and Cancer, held in Interlaken, Switzerland, Mar. 5-11, 1994.
Boyd et al., "Isolation and Characterization of a Novel Receptor-type Protein Tyrosine Kinase (hek) from a Human Pre-B Cell Line", J. Biol. Chem. 267:3262-3267, 1992.
Wicks et al., "Molecular Cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines", Proc. Natl. Acad. Sci. USA 89:1611-1615, 1992.
Wicks, "Molecular Characterisation of HEK, a Novel Human Receptor Tyrosine Kinase", Thesis for degree of Doctor of Philosophy, University of Melbourne, submitted Apr. 1992.
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