DNA encoding conserved T-cell receptor sequences

Details DNA encoding conserved T-cell receptor sequences DNA encoding conserved T-cell receptor sequences

1997-10-28

2000-07-04

Mertz, Prema

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 530324, 530326, 530330, C12N 1512, C07K 14725

Patent

active

060840870

ABSTRACT:
Four unique transcripts have been isolated from the .beta. chain of the T cell receptor in T cells in the synovial tissue of a patient with rheumatoid arthritis. Two of these transcripts were isolated from fresh synovial tissue and two were isolated from a T cell line derived from the synovial tissue. The sequences of the four transcripts are highly homologous, with a conserved amino acid sequence of IGQ.sub.-- N in the highly diverse V-D junction. The .alpha. chain and the antigenic specificity of the T cell line derived transcripts has also been characterized.

REFERENCES:
Grom et al. Proc. Natl. Acad. Sci. USA 90, 11104-11108, Dec. 1993.
Howell et al. (1991) Proc. Natl. Acad. Sci. USA 88, 10921-10925.
Lunardi et al. (1992) Clin. Exp. Immunol. 90, 440-446.
Zwillich et al. (1994) DNA and Cell Biol. 13, 923-931.
Jenkins et al. (1993) J. Clin. Invest. 92, 2688-2701.
Struyk et al. (1994) Intl. Immunol. 6, 897-907.
Pinschke et al. (1991) Eur. J. Immunol. 21, 2749-2751.
Paliard et al. (1991) Science 253, 325-329.
Friedberg et al. J. of Bacteriology. vol. 171, No. 11, pp. 6069-6076, 1989.
Kuhnel et al. Proc. Natl. Acad. Sci. USA vol. 86, pp. 2383-2387, 1989.
Yayon et al. The EMBO Journal vol. 11, No. 5, pp. 1885-1890, 1992.

Affiliated with

Also associated with

Rating

DNA encoding conserved T-cell receptor sequences does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA encoding conserved T-cell receptor sequences, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding conserved T-cell receptor sequences will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1487671