DNA encoding Chlamydia trachomatis isoleucyl tRNA synthetase pol

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 4353201, 435325, 536 237, C12P 2106, C12N 120, C12N 1500, C07H 2104

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active

060016027

ABSTRACT:
The invention provides ileS polypeptides and DNA (RNA) encoding ileS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ileS polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5075228 (1991-12-01), Nano et al.
Lazar et al (Molecular & Cellular Biology, vol. 8 No. 3, Mar. 1988 pp. 1247-1252).
Burgess et al (J. of Cell Biology vol. 111, Nov. 1990, pp. 2129-2138).
Salgaller et al (Cancer Immunol. Immunother. vol. 39 1994 pp. 105-116).
Frigerio et al (Biochimia et Biophysica Acta vol. 1262 1995 pp. 64-68).
Shiba et al., "Human cytoplasmic isoleucy-tRNA synthetase: Selective divergence of the anticodon-binding domain and acquisition of a new structure unit" Proc. Natl. Acad. Sci. USA, vol. 91, pp. 7435-7439, Aug. (1994) Biochemistry.

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