DNA encoding chimeric polypeptides comprising the interleukin-5

Details DNA encoding chimeric polypeptides comprising the interleukin-5 DNA encoding chimeric polypeptides comprising the interleukin-5

1992-09-16

1995-10-03

Draper, Garnette D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 536 2353, 435 691, 435 697, 435 702, 4352402, 4352523, 4353201, C07H 2104, C12N 121, C12N 510, C12N 1511

Patent

active

054553377

ABSTRACT:
Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.- and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy- or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.

REFERENCES:
Murata et al J. Exp. Med 175, 1992, pp. 341-351.
Groos et al, PNAS 86, 1989, pp. 10024-10028.
Aruffo and Seed, Proc. Natl. Acad. Sci. USA 84, 8573 (1987).
Birnboim and Doly, Nucl. Acids. Res. 7, 1513 (1979).
Clutterbuck et al., Eur. J. Immunol. 17, 1743-1750 (1987).
Cullen, Cell, 46, 973-982 (1986).
Felgner et al., Proc. Natl, Acad. Sci. USA 84, 7413-7417 (1987).
German, C., "DNA Cloning" (vol. II., edt. by Glover, D. M., IRL Press, Oxford, 1985).
Huck et al., Nucl. Acids Res. 14, 1779-1789 (1986).
Lopez et al., J. Exp. Med. 167, 219-224 (1988).
Malizewski and Fanslow, Tibtech., 8, 324-329 (1990).
Maniatis, T., Fritsch, E. F. and Sambrook, J., "Molecular Cloning", Cold Spring Harbor Lab. Press, USA (1982).
Neurath, H. and Hill, R. L. in "The Proteins", Academic Press, N.Y., 14 (1979).
Plaetinck et al., J. Exp. Med. 172, 683-691 (1990).
Rolink et al., J. Exp. Med. 169, 1693-1701 (1989).
Sambrook et al., "Molecular Cloning", 2nd ed., Cold Spring Harbor Laboratory Press, USA (1989).
Seed, Nature, 329, 840 (1987).
Seed and Aruffo, Proc. Natl. Acad. Sci. USA, 84, 3365 (1987).
Sharma, S. et al. in "Current Communications in Molecular Biology" edt. by Gething, M. J., Cold Spring Harbor Lab. Press USA (1985).
Traunecker et al., Nature 331, 84-86 (1988).
Yamaguchi et al., International Immunology 2, 181-187 (1990).
Takaki, S. et al., EMBO Journal, vol. 9, No. 13, pp. 4367-4374 (1990).
Patent Abstracts of Japan--JP-A-10 63 394, vol. 13, No. 262 (1989).
Takaki et al., Lymphokine Research, vol. 9, No. 4, pp. 572-S7.4 (1990).
The Journal of Experimental Medicine, vol. 172, No. 3, pp. 683-691 (1990).
Derwent Abstract No. 91-081851/12.
Derwent Abstract No. 92-009794/02.

Affiliated with

Also associated with

Rating

DNA encoding chimeric polypeptides comprising the interleukin-5 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA encoding chimeric polypeptides comprising the interleukin-5 , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding chimeric polypeptides comprising the interleukin-5 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1078309