DNA encoding canine granulocyte colony stimulating factor (G-CSF

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 696, 4351723, 4352404, 4352523, 4353201, 536 235, C07H 2104, C07K 100, C07K 14535, C12N 510

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054728576

ABSTRACT:
Compositions and methods for treating or preventing infections in canine or feline animals which comprises administering an effective amount of granulocyte colony stimulating factor (G-CSF), are disclosed. The G-CSF may be naturally derived, or alternatively, the G-CSF and genetically engineered variants of G-CSF may be the expression products of genetically engineered prokaryotic or eukaryotic host cells.

REFERENCES:
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Tsuchiya et al, "Isolation and Characterization of the cDNA for Murine Granulocyte Colony-Stimulating Factor", Immunobiology 172: 175-184 (1986).
Nagata et al., "The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor", EMBO Journal, 5(3): 575-581 (Mar. 1986).
Tsuchiya et al, "Characterization of recombinant human granulocyte colony-stimulating factor produced in mouse cells", EMBO Journal, 6(3): 611-616 (1987).
Neumeier and Maurer, "Isolation of a High Molecular Mass Granulocyte Colony-Stimulating Factor from Bovin Lung Conditioned Medium", Hoppe Seyler's Z. Physiol. Chemistry, 363: 1493-1500 (Dec. 1982
Schuening et al., "Effect of Recombinant Granulocyte Colony-Stimulating Factor on Hematopoiesi of Normal Dogs and on Hematopoietic Recovery After Otherwise Lethal Total Body Irradiation", Blood, 74: 1308-1313 (1989).
Lothrop et al, "Correction of canine cyclic hematopoiesis with recombinant human granulocyte colony-stimulating factor", Chemical Abstracts, 109: 642-643 (1988).
Matsumoto, "Protective Effect of Human Granulocyte Colony-Stimulating Factor on Microbial Infection in Neutropenic Mice", Infection and Immunity, 55: 2715-2720 (1987).

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