DNA encoding calcium-signal modulating cyclophilin ligand

Details DNA encoding calcium-signal modulating cyclophilin ligand DNA encoding calcium-signal modulating cyclophilin ligand

1994-06-17

1996-06-04

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 235, C12N 508, C12N 1512

Patent

active

055232272

ABSTRACT:
DNA and protein compositions are provided for calcium-signal modulating cyclophilin ligand which are shown to act in the calcium-dependent pathway for activation of a number of genes. The DNA composition and proteins may be used in investigating the processes associated with calcium-dependent activation of genes, as well as screening of drugs for interaction with the subject proteins for modulating cell processes, e.g. T-cell activation.

REFERENCES:
Friedman et al., "Cloning and Characterization of Cyclophilin C-Associated Protein: A Candidate Natural Cellular Ligand for Cyclophilin C," Proc. Natl. Acad. Sci. USA (1993) 90:6815-6819.
Friedman and Weissman, "Two Cytoplasmic Candidates for Immunophilin Action Are Revealed by Affinity for a New Cyclphilin: One in the Presence and One in the Absence of CsA," Cell (1991) 66:799-806.

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