Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-04-15
1998-01-27
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 536 235, C12N 1512, C12N 510
Patent
active
057121117
ABSTRACT:
DNAs encoding bradykinin B.sub.1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Arg.sup.10 kallidin and other B.sub.1 -specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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Bierilo Kathleen K.
Borkowski Joseph A.
Hess John W.
Linemeyer David L.
Menke John G.
Hand J. Mark
Merck & Co. , Inc.
Tribble Jack L.
Ulm John
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