DNA encoding bovine pancreatic cholesterol esterase

Details DNA encoding bovine pancreatic cholesterol esterase DNA encoding bovine pancreatic cholesterol esterase

1995-06-05

1997-04-29

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352523, 435198, 4353201, 435348, 435419, 435358, 536 232, C12N 920, C12N 1555

Patent

active

056248369

ABSTRACT:
The invention provides methods for the purification to homogeneity of pancreatic cholesterol esterase in useful quantities from a variety of mammalian species. The gene for a mammalian pancreatic cholesterol esterase has been cloned and sequenced, and is useful for expressing cholesterol esterase in a transformed eukaryotic or prokaryotic cell culture. Thus, methods according to the invention enable the production of large quantities of pancreatic cholesterol esterase for the screening of inhibitors, the production of antibodies, and for commercial purposes related to the alteration of cholesterol/cholesterol ester composition of materials containing free or esterified cholesterol.

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